Yes — Ultimate Spike Detox may support circulation, inflammation, and immune balance, but there’s no clinical proof it flushes spike proteins from your body. Launched by The Wellness Company in 2025, it combines nattokinase, bromelain, and curcumin — enzymes and botanicals with early lab studies suggesting they help break down protein fragments and support immune function.
In this review, I’ll cover what it really does, whether it’s safe, when to take it, how long it works, and how it compares to other “spike protein detox” supplements on Amazon.
What Is Ultimate Spike Detox?
Ultimate Spike Detox is a supplement made by The Wellness Company, a brand that’s been featured heavily in conservative media like Fox News. It’s marketed as a way to help your body detox from lingering spike proteins — the same proteins your body creates in response to COVID-19 infection or mRNA vaccines like Pfizer and Moderna.
It’s not positioned as a cure or treatment for any disease — but the messaging suggests it could help with things like:
- Long-haul COVID symptoms
- Post-vaccine fatigue or inflammation
- Circulatory or immune imbalances
It’s essentially sold as a “cellular cleanup” formula for people worried that spike proteins are still affecting their body months later.
Is Ultimate Spike Detox Good?
Yes — Ultimate Spike Detox may be helpful for circulation, inflammation, and immune balance, but results will vary. Its key ingredients have some promising lab studies, but no clinical trials confirm it removes spike proteins. For some people, it may support recovery and energy, while others might notice little change.
Is Ultimate Spike Detox Safe?
Ultimate Spike Detox uses natural enzymes and botanicals like nattokinase, bromelain, and curcumin. Most adults tolerate these ingredients well, but there are safety notes:
- Blood thinners / clotting disorders: Nattokinase can thin blood.
- Digestive sensitivity: Bromelain and curcumin can cause stomach upset for some.
- Medical conditions / medications: Always consult a doctor first.
Bottom line → Safe for most healthy adults, but not for everyone.
What Does Ultimate Spike Detox Claim to Do?
According to the company, this supplement is designed to:
- Break down spike protein fragments that may remain after COVID or mRNA vaccination
- Support immune regulation and inflammation control
- Promote cardiovascular and cellular health
Their website mentions concerns about spike proteins contributing to blood clotting, inflammation, and immune dysfunction. The implication is that your body might not clear these proteins fast enough on its own — and this product might help.
It’s less about curing illness — and more about supporting your body’s recovery systems after a major immune event.
Key Ingredients: What’s Actually in It?
These ingredients are well-studied individually, but there’s no proof this exact combo removes spike proteins in humans.
1. Nattokinase
A natural enzyme from fermented soybeans. Known for breaking down fibrin and supporting healthy circulation. One 2022 study found that nattokinase degraded spike protein fragments in vitro (lab setting only), with effects increasing by dose and time. source.
2. Bromelain
An enzyme from pineapple stems that reduces inflammation and oxidative stress, often used for digestive and sinus support. A 2020 lab study found that bromelain inhibits SARS‑CoV‑2 infection in cultured cells by degrading spike protein and key entry mechanisms. source.
3. Curcumin
The active compound in turmeric, known for its powerful antioxidant and anti-inflammatory effects. Some early lab and animal studies suggest it helps regulate immune responses and inhibit viral activity. source.
Each of these ingredients has some research behind it. But no clinical studies have proven this exact combo can “remove” spike protein from your body.
When Should You Take Ultimate Spike Detox?
Most users take 2 capsules daily with food, usually at breakfast or lunch.
- Taking it earlier in the day reduces chances of stomach upset.
- Consistency matters more than exact timing.
- Avoid combining with other strong blood thinners unless your doctor approves.
How Long Does Ultimate Spike Detox Work?
There’s no evidence this product permanently clears spike proteins. Most people take it for 30–60 days. Some notice benefits in circulation and energy within weeks, but results vary.
Why Do a Spike Protein Detox?
The idea of a “spike protein detox” comes from concerns that spike proteins linger after COVID infection or vaccination.
- Your body naturally clears proteins over time.
- Supplements like nattokinase and bromelain are marketed to support circulation and immune balance.
- There’s no proof supplements “flush” spike proteins — but they may support overall recovery.
Ultimate Spike Detox vs Other “Spike Protein Detox” Supplements (June 2025)
When I searched Amazon, I found a flood of similar supplements using the same buzzwords: “flush spike protein,” “post-vaccine detox,” “immune cleanse.”
Here are the three most common ones and how they compare — not just in ingredients, but price per serving:
Most formulas have overlap in ingredients, but vary widely in transparency, quality, and pricing.
$89.99 for 120 capsules (60 servings) → ~$1.50 per serving
Key ingredients: Nattokinase, Bromelain, Curcumin, Selenium, Dandelion, Black Seed, Turmeric with Black Pepper
Professional, doctor-backed formula supported by Dr. Peter McCullough. Clean ingredient profile, non-GMO, gluten-free, and made in a GMP-certified facility. Higher price, but positioned as a premium, clinical-grade option.
$29.99 for 60 capsules (30 servings) → ~$1.00 per serving
Key ingredients: Nattokinase (4,000 FU), Bromelain, Curcumin, Green Tea, Black Cumin Seed, Dandelion, Selenium, Irish Sea Moss
More affordable, with an extensive list of trendy detox ingredients. However, the formula feels like a catch-all approach without clear synergy or dosing rationale. Could work, but doesn’t inspire the same trust as doctor-developed options.
Base Spike Protien Detox B&B Global
$59.94 for 60 capsules (30 servings) → ~$2.00 per serving
Key ingredients: Nattokinase, Bromelain, Curcumin, Garlic, Ginger, Vitamin C, Black Pepper
Small-business product with a holistic edge. Combines detox staples with classic immune-support ingredients like garlic and vitamin C. A solid blend overall, but less transparent about exact dosages and clinical backing.
Prices are approximate as of September 2025.
Please note that product costs may vary slightly depending on where you purchase, available discounts, and shipping fees.
Final Thoughts: Do You Actually Need It?
Ultimate Spike Detox may support circulation, immunity, and inflammation — but there’s no clinical proof it clears spike proteins from your body. Your liver, lymph, and immune system remain your body’s real detox team.
That doesn’t make the product a scam, but it’s not a magic fix either. Some people might feel better energy or recovery support, while others may notice little difference. If you’re considering it, make sure your foundations are covered first:
- Eat real, nutrient-dense foods and stay hydrated
- Prioritize quality sleep and daily movement
- Consider foundational support like a high-quality multivitamin or immune-boosting mushrooms
Bottom line: detox supplements can play a supportive role, but real recovery comes from consistent healthy habits and supporting your body’s core systems.
FAQ: Spike Protein Detox Questions (2025)
Q: Does Ultimate Spike Detox actually remove spike protein?
A: There’s no clinical proof it removes spike protein. Some lab studies suggest nattokinase might break it down in vitro, but no human trials have confirmed this.
Q: Is Ultimate Spike Detox safe?
A: Most people tolerate the ingredients well, but consult your doctor — especially if you’re on blood thinners or have medical conditions.
Q: Should I take this if I’m vaccinated?
A: The product is marketed to both post-COVID and post-vaccine audiences. Whether it’s needed is debatable — most effects should resolve over time naturally.
Q: What’s a good alternative?
A: Try supporting detox naturally through a gentle parasite cleanse or adding adaptogens like ashwagandha for stress and inflammation.
Q: How do you take Ultimate Spike Detox?
A: The standard dose is 2 capsules daily with food. Always follow label directions unless your healthcare provider says otherwise.
Q: How long should you take Ultimate Spike Detox?
A: Most people take it for 30–60 days, depending on how they feel. There’s no long-term safety data, so take breaks and monitor how your body responds.
Q: What’s the difference between Ultimate Spike Detox and Ultimate Gold Detox?
A: They’re unrelated. Ultimate Spike Detox is marketed for post-COVID and immune support. Ultimate Gold Detox is a synthetic urine cleanser sold for drug testing — not for health or detox.
Q: Does Ultimate Spike Detox work for everyone?
A: Effects vary. Some people report better energy or clarity, while others feel no change. There’s no guarantee since it’s not backed by clinical trials.
Q: Is Ultimate Spike Detox good?
A: Ultimate Spike Detox may support circulation, inflammation, and immune balance thanks to ingredients like nattokinase, bromelain, and curcumin. However, there’s no clinical proof it clears spike proteins. Some people report more energy and recovery, while others notice little difference.
Q: When should I take Ultimate Spike Detox?
A: The standard dose is 2 capsules daily with food. Most users take it with breakfast or lunch to reduce stomach upset. Consistency is more important than exact timing, so aim to take it around the same time each day.
Q: How long does Ultimate Spike Detox work?
A: Most people use it for 30–60 days. Some report noticing circulation or energy benefits within weeks, but results vary. There’s no evidence it permanently removes spike proteins, so it should be viewed as a supportive supplement, not a cure.
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Health Disclaimer
This post is for informational purposes only and is not intended to diagnose, treat, or cure any condition. The content reflects personal research and opinion, and should not be taken as medical advice. Always consult with a qualified healthcare provider before starting any new supplement, detox protocol, or treatment — especially if you have existing health conditions or take medication.
Devin Brundell is the founder of Brundell Co., a wellness platform dedicated to natural healing, lifestyle medicine, and intentional living. He holds a Bachelor’s degree in Business Management from Southwest Minnesota State University (SMSU) and a Bachelor’s in Holistic Health Sciences from Quantum University. Devin is also finalizing certification as a Board Certified Holistic Health Practitioner through the AADP. His mission is to empower others to reclaim health through practical tools, clean living, and purpose-driven change — one intentional choice at a time.